EPA Science Inventory

BIOLOGICAL EFFECTS OF OIL FLY ASH AND RELEVANCE TO AMBIENT AIR PARTICULATE MATTER

Citation:

Ghio, A J., R Silbajoris, J. Carson, AND J M. Samet. BIOLOGICAL EFFECTS OF OIL FLY ASH AND RELEVANCE TO AMBIENT AIR PARTICULATE MATTER. ENVIRONMENTAL HEALTH PERSPECTIVES 110(1):89-94, (2002).

Description:

Epidemiologic studies have demonstrated increased human morbidity and mortality with elevations in the concentration of ambient air particulate matter (PM). Fugitive fly ash from the combustion of oil and residual fuel oil significantly contributes to the ambient air particle burden. Residual oil fly ash (ROFA) is remarkable in the capacity to provoke injury in experimental systems. The unique composition of this emission source particle makes it particularly useful as a surrogate for ambient air PM in studies of biologic effects testing the hypothesis that metals mediate the biologic effects of air pollution particles. A majority of the in vitro and animal model investigations support the postulate that transition metals present in ROFA (especially vanadium) participate in Fenton-like chemical reactions to produce reactive oxygen species. This is associated with tyrosine phosphorylation, nuclear factor kappa B and other transcription factor activation, induction of inflammatory mediator expression, and inflammatory lung injury. It is also evident that vanadium accounts for a significant portion of the biologic activity of ROFA. The extrapolation of this body of investigation on ROFA to the field of ambient air PM is difficult, as particles in numerous environments have such small amounts of vanadium.

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Start Date: 02/01/2002
Completion Date: 02/01/2002
Record Last Revised: 12/22/2005
Record Created: 05/04/2004
Record Released: 05/04/2004
Record ID: 81589

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB

HUMAN STUDIES DIVISION

CLINICAL RESEARCH BRANCH