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EFFECTS OF METHOPRENE DERIVATIVES ON THE EXPRESSION OF RETINOIC ACID SENSITIVE GENES AND PROTEINS IN CULTURED CELLS
Citation:
EFFECTS OF METHOPRENE DERIVATIVES ON THE EXPRESSION OF RETINOIC ACID SENSITIVE GENES AND PROTEINS IN CULTURED CELLS. Presented at SETAC 20th Annual Meeting, Philadelphia, PA, November 14-18, 1999.
Description:
The insect juvenile hormone analog methoprene has been suggested as a possible cause of malformations in frogs and other amphibians. Methoprene has structural similarities to the ubiquitous development regulator, retinoic acid, and thus, may bind to retinoid receptors and consequently interfere with retinoid-regulated gene transcription. These data suggest that methoprene derivatives can act as potent retinoid analogs, but that certain cell types may not be able to metabolize the parent compound into active forms. Further analysis of methoprene derivatives is warranted.