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GENOMIC ANALYSIS OF SURROGATE TISSUES FOR ASSESSING ENVIRONMENTAL EXPOSURES AND FUTURE DISEASE STATES
Citation:
Rockett, J C., C. BLYSTONE, A. GOETZ, R. MURRELL, H. REN, J. E. SCHMID, J. STAPELFELDT, L. F. STRADER, K. E. THOMPSON, D. B. TULLY, P. ZIGAS, AND D. J. DIX. GENOMIC ANALYSIS OF SURROGATE TISSUES FOR ASSESSING ENVIRONMENTAL EXPOSURES AND FUTURE DISEASE STATES. Presented at National Children's Study, Baltimore, MD, December 17 - 18, 2002.
Description:
Genomic Analysis of Surrogate Tissues for Assessing Environmental Exposures and Future Disease States
John C. Rockett, Chad R. Blystone, Amber K. Goetz, Rachel N. Murrell, Hongzu Ren, Judith E. Schmid, Jessica Stapelfeldt, Lillian F. Strader, Kary E. Thompson, Douglas B. Tully, Paul Zigas and David J. Dix
Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
Abstract
Genomics technology has made it possible to define molecular physiology in exquisite detail, when tissues are accessible for sampling. However, many target tissues are not accessible for human diagnostic evaluations or experimental studies, creating the need for accessible surrogates that afford insight into exposures and effects in the target tissues. Surrogate tissue analysis (STA) incorporating contemporary genomic technologies may be useful in determining toxicant exposure and effect, or disease state, in target tissues at the pre- or early clinical stage. We have proposed that gene expression changes in accessible tissues such as blood, hair follicles and sperm will often reflect those in inaccessible tissues, thus offering a convenient biomonitoring method to provide insight into the effects of environmental toxicants on target tissues and reveal early biomarkers of adverse effects prior to clinical manifestation. We are conducting a series of studies in rodent and human models to assess the utility of STA and its applicability to the National Children?s Study. This is an abstract of a proposed presentation and does not necessarily reflect EPA policy