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USE OF THE TEQ MODEL FOR ASSESSING AHR MEDIATED TOXICITY RISKS TO POPULATIONS OF LAKE TROUT AND OTHER SPECIES IN LAKE ONTARIO
Citation:
Cook, P. M. AND R. E. Peterson. USE OF THE TEQ MODEL FOR ASSESSING AHR MEDIATED TOXICITY RISKS TO POPULATIONS OF LAKE TROUT AND OTHER SPECIES IN LAKE ONTARIO. DIOXIN 2003: 23rd International Symposium of Halogenated Organic Pollutants and Persistent Organic Pollutants, Boston, MA, August 24-29, 2003.
Description:
The toxicity equivalence (TEQ) model for assessing aryl hydrocarbon receptor (AHR) mediated toxicity risks associated with polyhalogenated aromatic chemicals structurally similar to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has been applied to human health risks for more than 15 years... By the middle of the 20th century, the Great Lakes were highly contaminated with TCDD and other AHR agonists for which TEFs are now available. Simultaneously, populations of some fish and bird species declined... The retrospective analysis of the decline of lake trout in Lake Ontario and difficulties in restoring a naturally reproducing population provides a compelling example of the importance and effectiveness of the TEQ model.