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CHANGES IN THE DNA-BINDING OF SEVERAL TRANSCRIPTION FACTORS IN THE DEVELOPING RAT CEREBELLUM BY PCBS.
Citation:
Basha, M. R., N. S. Braddy, P. Kodavanti, AND N. H. Zawia. CHANGES IN THE DNA-BINDING OF SEVERAL TRANSCRIPTION FACTORS IN THE DEVELOPING RAT CEREBELLUM BY PCBS. Presented at ( Dioxin 2002) 22nd International Symp on Halogenated Environ. Pollutants and POPs, Barcelona, Spain, 8/11-16/2002.
Description:
PCBs are a class of persistent halogenated aromatic hydrocarbon chemical pollutants and considered as one of the major environmental contaminants resulting from intensive industrial use and inadequate disposal. In utero exposure to PCBs has been known to cause delayed neuronal development, cognitive deficits and motor dysfunction1-2. The cellular and molecular basis for PCB-induced developmental neurotoxicity is still unclear, however, a series of in vitro and some in vivo studies have revealed that the disruption of Ca2+ homeostasis and Ca2+ mediated signal transduction play a significant role3-4. Since the culminating event in a variety of signal transduction pathways is the regulation of gene expression5, we examined the DNA-binding of several transcription factors such as specificity protein (Sp1), activator protein (AP-1), nuclear factor kappa-B (NF?B) and cAMP-responsive element modulator (CREB) in order to identify those that are involved in signal transduction/transcription coupling in the developing brains of PCB-exposed animals.