EPA Science Inventory

A PHYSIOLOGICALLY BASED TOXICOKINETIC MODEL FOR DIETARY UPTAKE OF HYDROPHOBIC ORGANIC COMPOUNDS BY FISH: I. FEEDING STUDIES WITH 2,2',5,5'-TETRACHLOROBIPHENYL

Citation:

Nichols, J. W., P N. Fitzsimmons, F W. Whiteman, T D. Dawson, L. Babeu, AND J. A. Juenemann. A PHYSIOLOGICALLY BASED TOXICOKINETIC MODEL FOR DIETARY UPTAKE OF HYDROPHOBIC ORGANIC COMPOUNDS BY FISH: I. FEEDING STUDIES WITH 2,2',5,5'-TETRACHLOROBIPHENYL. TOXICOLOGICAL SCIENCES 77(2):206-218, (2004).

Description:

A physiologically-based toxicokinetic (PBTK) model was developed to describe dietary uptake of hydrophobic organic compounds by fish. The gastrointestinal (GI) tract was modeled using four compartments corresponding to the stomach, pyloric ceca, upper intestine, and lower intestine, and the lumenal volume of each compartment was allowed to change in time as a function of bulk flow down the GI tract and (for the pyloric ceca and upper intestine) nutrient intake. --- The model accurately describes observed patterns of gastric evacuation and bulk flow of digesta, the concentration time-course for TCB in contents and tissues of the GI tract, and TCB distribution to other major tissues. Most of the TCB was taken up in the pyloric ceca and upper intestine during the period of peak lipid absorption. It is concluded, however, that a kinetic limitation acting along the entire length of the GI tract resulted in a chemical disequilibrium between feces and tissues of the lower intestine.

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Start Date: 02/25/2004
Completion Date: 02/25/2004
Record Last Revised: 12/22/2005
Record Created: 03/02/2004
Record Released: 03/02/2004
Record ID: 76583

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB

MID-CONTINENT ECOLOGY DIVISION

ECOTOXICOLOGY ANALYSIS RESEARCH