Description:

ERDEM is a physiologically based pharmacokinetic (PBPK) modeling system consisting of a general model and an associated front end. An actual model is defined when the user prepares an input command file. Such a command file defines the chemicals, compartments and processes that are to be used. A graphical-user-interface (GUI) Front End is utilized to prepare the input data.

Record Details:

Record Type:MODEL

Product Published Date:01/23/2004

Record Last Revised:10/08/2009

Record ID: 75972

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Model Detail:

Model Evaluation :Extensive QA and testing procedures followed with each enhancement; specific test data sets are maintained for testing and evaluation purposes; comparisons are made with independent data sets.

Model URL :http://www.epa.gov/heasd/products/erdem/erdem.htm

Model Guidance Documents :http://www.epa.gov/heasd/products/erdem/237edrb05-Report.pdf

Model Decision Documents :Video Tutorial, Extensive Help, and Release Notes

Model Download Information :The download of the ERDEM model is in preparation. The ERDEM GUI Front End for the latest model is in development. The ERDEM 3.6a beta may be made available for review. It does not contain enzyme inhibition and certain dermal exposure types.

See the model's home page for download information.

modelcontactinfo :Agency Contact: Rogelio Tornero-Valez
Human Exposure and Atmospheric Sciences Division
National Exposure Research Lab
Office of Rearch and Development
U.S. EPA
tornero-velez.rogelio@epa.gov
919-541-9447

Cecilia Tan
Human Exposure and Atmospheric Sciences Division
National Exposure Research Lab
Office of Rearch and Development
U.S. EPA
tan.cecilia@epa.gov
919-541-2542

Model Inputs :The inputs consist of the user's choice of lung, GI, or dermal model, and the other compartments. Then the user chooses the processes to model, such as binding, elimination, metabolism, and enzyme inhibition (if included). The physiological parameters such as body weight and compartment weight, cardiac output, breathing rate and blood flow to each compartment are input for the chosen species. The partition coefficients for the flow of chemical throughout the blood and compartments are then input. The metabolism, binding, elimination and inhibition parameters are input.

Model Outputs :These consist of time profiles of amount, concentration, Area Under the Curve and other outputs as desired by the user. Plots can be generated by the model, and time profiles can be printed for inserting into other plotting packages.

Model Computer Requirements:

Model Operating Systems Needs :Microsoft Windows 98, NT 4.0, 2000, or XP

Model Hardware Needs :Minimum 700 MHz chip with at least 512 Megabytes of RAM

Model Programming Language(s) :Advanced Continuous Simulation Language (ACSL), Compaq Visual Fortran, Power Builder, Read only model is run with the ACSL Viewer

other_req :A User's Guide, Video Tutorial, Extensive Help, and Release Notes are supplied with the ERDEM system.