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CYTOGENETIC STUDIES IN MICE TREATED WITH THE JET FUELS, JET-A AND JP-8
Vijayalaxmi,, A D. Kligerman, T. J. Phihoda, AND S. E. Ullrich. CYTOGENETIC STUDIES IN MICE TREATED WITH THE JET FUELS, JET-A AND JP-8. Sixth International Symposium on Chromosome Aberrations, Essen, Germany, 09/10-13/03.
Cytogenetic studies in mice treated with the jet fuels, Jet-A and JP-8
The genotoxic potential of the jet fuels, Jet-A and JP-8, were examined in mice treated on the skin with a single dose of 240 ug/mouse. Peripheral blood smears were prepared at the start of the experiment (t = 0), and at 24, 48 and 72 hours following treatment with jet fuels. Femoral bone marrow smears were made when all animals were sacrificed at 72 hours. In both tissues, the extent of genotoxicity was determined from the incidence of micronuclei (MN) in polychromatic erythrocytes. The frequency of MN in the peripheral blood of mice treated with Jet-A and JP-8 increased over time and reached statistical significance at 72 hours, as compared with concurrent control animals. The incidence of MN was also higher in bone marrow cells of mice exposed to Jet-A and JP-8 (compared with controls). Thus, at the dose tested, a small but significant genotoxic effect of jet fuels was observed in the blood and bone marrow cells of mice treated on the skin.
Record Details:Record Type: DOCUMENT (PRESENTATION/PAPER)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY
ENVIRONMENTAL CARCINOGENESIS DIVISION
CELLULAR TOXICOLOGY BRANCH