EPA Science Inventory

NEUROTOXICITY OF TETRACHLOROETHYLENE (PERCHLOROETHYLENE): DISCUSSION PAPER

Citation:

U.S. EPA. NEUROTOXICITY OF TETRACHLOROETHYLENE (PERCHLOROETHYLENE): DISCUSSION PAPER.

Description:

This paper is a background document for a meeting of neurotoxicity experts to discuss the central nervous system effects of exposure to perchloroethylene (perc). The document reviews the literature on neurological testing of people exposed to perc occupationally in dry cleaning facilities and on people living near dry cleaning facilities. It also reviews the neurobehavioral studies of laboratory animals exposed to perc via inhalation. The reports describe impairment of visual information processing and other adverse neurobehavioral effects in several studies of employees working in dry cleaning facilities using perc. Two studies of people living near dry cleaning facilities have also shown neurological effects, and their exposures have been at lower concentrations than the workers and the specific neurological tests used in the residential studies have been different. The expert panel will discuss issues centering on the question of whether this limited information at lower exposures is strong enough to infer that low concentrations of perc is a hazard to the general population.

Purpose/Objective:

Discussion paper.

Record Details:

Record Type: DOCUMENT (PRESENTATION/PAPER)
Start Date: 10/01/2003
Completion Date: 10/01/2003
Record Last Revised: 12/07/2011
Record Created: 12/03/2003
Record Released: 12/03/2003
OMB Category: Other
Record ID: 75193

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL CENTER FOR ENVIRONMENTAL ASSESSMENT