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URINARY MUTAGENICITY AND COLORECTAL ADENOMA RISK
Peters, U., D M. DeMarini, R. Snha, L R. Brooks, S H. Warren, N. Chatterjee, AND N. Rothman. URINARY MUTAGENICITY AND COLORECTAL ADENOMA RISK. CANCER EPIDEMIOLOGY, BIOMARKERS, AND PREVENTION 12(11):1253-1256, (2002).
We investigated urinary mutagenicity and colorectal adenoma risk in a clinic-based, case-control study of currently nonsmoking cases (n = 143) and controls (n = 156). Urinary organics were extracted by C18/methanol from 12-h overnight urine samples, and mutagenicity was determined in Salmonella YG1024 +S9 (Ames test). Adenoma risk was 2.4-fold higher in subjects in the highest vs. lowest quintile of urinary mutagenicity [95% confidence interval (CI) = 1.1-5.1]. Combining urinary mutagenicity with intake of meat-derived mutagenicity (from our earlier analysis) resulted in a 5.6-fold increase in adenoma risk (95% CI = 2.2-13.9, comparing highest to lowest quintile). In our study population, diet may contribute to mutagenic exposure, which was positively associated with colorectal adenoma risk.
Record Details:Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB
ENVIRONMENTAL CARCINOGENESIS DIVISION
MOLECULAR TOXICOLOGY BRANCH