EPA Science Inventory

URINARY MUTAGENICITY AND COLORECTAL ADENOMA RISK

Citation:

Peters, U., D M. DeMarini, R. Snha, L R. Brooks, S H. Warren, N. Chatterjee, AND N. Rothman. URINARY MUTAGENICITY AND COLORECTAL ADENOMA RISK. CANCER EPIDEMIOLOGY, BIOMARKERS, AND PREVENTION 12(11):1253-1256, (2002).

Description:

Abstract

We investigated urinary mutagenicity and colorectal adenoma risk in a clinic-based, case-control study of currently nonsmoking cases (n = 143) and controls (n = 156). Urinary organics were extracted by C18/methanol from 12-h overnight urine samples, and mutagenicity was determined in Salmonella YG1024 +S9 (Ames test). Adenoma risk was 2.4-fold higher in subjects in the highest vs. lowest quintile of urinary mutagenicity [95% confidence interval (CI) = 1.1-5.1]. Combining urinary mutagenicity with intake of meat-derived mutagenicity (from our earlier analysis) resulted in a 5.6-fold increase in adenoma risk (95% CI = 2.2-13.9, comparing highest to lowest quintile). In our study population, diet may contribute to mutagenic exposure, which was positively associated with colorectal adenoma risk.

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Start Date: 11/01/2003
Completion Date: 11/01/2003
Record Last Revised: 12/22/2005
Record Created: 12/02/2003
Record Released: 12/02/2003
Record ID: 75173

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB

ENVIRONMENTAL CARCINOGENESIS DIVISION

MOLECULAR TOXICOLOGY BRANCH