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EXPEDITIOUS SOLVENT-FREE ORGANIC SYNTHESES USING MICROWAVE IRRADIATION
Citation:
Varma*, R S. EXPEDITIOUS SOLVENT-FREE ORGANIC SYNTHESES USING MICROWAVE IRRADIATION. Chapter 23, Anastas, P.T., Heine, L.G., Williamson, T.C. (ed.), ACS Symposium Series 767 - Green Chemical Syntheses and Processes. American Chemical Society, Washington, DC, , 292-312, (2000).
Description:
Microwave-expedited solvent-free synthetic processes involve the exposure of neat reactants to microwave (MW) irradiation in the presence of supported reagents or catalysts on mineral oxides. Recent developments are described and the salient features of these high yield protocols, namely the enhanced reaction rates, greater selectivity and the experimental ease of manipulation are highlighted. Research from our laboratory on the use of supported reagents or recyclable mineral oxides such as Fe(NO)3-clay (clayfen), Cu(NO3)2-clay (claycop), NH4NO3-clay (clayan), NH4OH-clay, PhI(OAc)2-alumina, NaIO4-silica, CrO3-alumina, MnO2-silica, and NaBH4-clay etc. and their role in MW-promoted deprotection, condensation, cyclization, rearrangement, oxidation and reduction reactions including the rapid one-pot assembly of useful heterocyclic compounds from in situ generated intermediates, are described.