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DISCRIMINATING REDOX CYCLING AND ARYLATION PATHWAYS OF REACTIVE CHEMICAL TOXICITY IN TROUT HEPATOCYTES
Citation:
Schmieder, P. K., M A. Tapper, R C. Kolanczyk, D E. Hammermeister, B R. Sheedy, AND J. S. Denny. DISCRIMINATING REDOX CYCLING AND ARYLATION PATHWAYS OF REACTIVE CHEMICAL TOXICITY IN TROUT HEPATOCYTES. TOXICOLOGICAL SCIENCES 72:66-76, (2003).
Description:
The toxicity of four quinones, 2,3-dimethoxy-1,4-naphthoquinone (DMONQ), 2-methyl-1,4-naphthoquinone (MNQ), 1,4-naphthoquinone (NQ), and 1,4-benzoquinone (BQ), which redox cycle or arlyate in mammalian cells, was determined in isolated trout (Oncorhynchus mykiss) hepatocytes. More than 70% of cells died in 3 h when exposed to BQ or NQ; 50% died in 7 h when exposed to MNQ, with no mortality compared to controls after 7 h DMONQ exposure. A suite of biochemical parameters was assessed for ability to discrininate these reactivity pathways in fish.