EPA Science Inventory

DEVELOPMENTAL EVALUATION OF A POTENTIAL NON-STEROIDAL ESTROGEN: TRICLOSAN

Citation:

Foran, C M., E. R. Bennett, AND W H. Benson. DEVELOPMENTAL EVALUATION OF A POTENTIAL NON-STEROIDAL ESTROGEN: TRICLOSAN. MARINE ENVIRONMENTAL RESEARCH 50(1-5):153-156, (2000).

Description:

Triclosan is an antibacterial agent commonly used in industry and often detected in wastewater effluent. The potential of triclosan to act as an endocrine disruptor was examined because its chemical structure closely resembles known non-steroidal estrogens (e.g. DES, bis-phenol A). Japanese medaka fry (Oryzias latipes) were exposed for 14 days beginning 2 days post-hatch to triclosan (100, 10, 1 ?g/l), or a solvent control (ethanol). Two months post-exposure, the phenotypic sex of each adult was assessed visually using sexually dimorphic fin shape and size. The proportion of females in each group was similar for triclosan-exposed animals and solvent-treated controls (ethanol 53%, 1 ppb 58%, 10 ppb 45%, 100 ppb 36%) although E2 treatment did produce 92% female adults. Sexually dimorphic fin traits were quantified to look for potential effects of triclosan and E2 on the development of secondary sexual characters. These results do not support the hypothesis that triclosan is potently estrogenic. However, changes in fin length and non-significant trends in sex ratio suggest triclosan is potentially weakly androgenic.

Record Details:

Record Type: DOCUMENT (JOURNAL/PEER REVIEWED JOURNAL)
Start Date: 12/30/2000
Completion Date: 12/30/2000
Record Last Revised: 12/22/2005
Record Created: 09/26/2003
Record Released: 09/26/2003
Record ID: 64713

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LAB

GULF ECOLOGY DIVISION

IMMEDIATE OFFICE