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ACCUMULATION AND EFFECTS OF PFOS ON THE REPRODUCTIVE ENDOCRINOLOGY OF THE FATHEAD MINNOW
Citation:
Kuehl, D W., K M. Jensen, M D. Kahl, A. L. Linnum, R. D. Johnson, K. M. Flynn, AND G T. Ankley. ACCUMULATION AND EFFECTS OF PFOS ON THE REPRODUCTIVE ENDOCRINOLOGY OF THE FATHEAD MINNOW. Presented at SETAC Annual Meeting, Austin, TX, November 9-13, 2003.
Description:
Perfluorooctane sulfonate (PFOS) is a globally-distributed contaminant in fish and wildlife. Comparatively little is known, however, concerning potential adverse effects of PFOS on reproduction and development of fish. There is some indication that PFOS could affect reproductive endocrine function, possibly through alterations in the metabolism/distribution of sex steroids. The goal of this study was to utilize a recently-developed assay with the fathead minnow, designed to detect specific classes of endocrine-disrupting chemicals, to assess the effects of PFOS on reproductive capacity and early development of fish. In addition, bioconcentration and tissue distribution of the PFOS was determined so that effects could be related directly to dose. This paper will present results of the reproductive study, including analysis of endocrine-related endpoints in the adult fish, as well as data concerning survival and development of the F1 offspring. Adverse effects will be related to measured concentrations of PFOS in selected tissues of both the adult and larval animals.