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RELATIVE BINDING AFINITY OF ALKYLPHENOLS TO RAINBOW TROUT ESTROGEN RECEPTOR
Citation:
Henry, T. M., J. S. Denny, AND P. K. Schmieder. RELATIVE BINDING AFINITY OF ALKYLPHENOLS TO RAINBOW TROUT ESTROGEN RECEPTOR. Presented at Joint Regional SETAC/SOT Annual Meetings, USEPA, Duluth, MN, April 9-10, 2002.
Description:
The USEPA has been mandated to screen industrial chemicals and pesticides for potential endocrine activity. The appropriateness of extrapolating mammalian results to non-mammalian species is uncertain; primarily due to the lack of non-mammalian data for making such an assessment. The pprimary objective of this study was to establish the relative binding affinity of a number of alkylhenols in a widely used non-mammalian toxicity model, the rainbow trout. - - -
Comparison of the trout RBAs to mammalian RBAs indicates cross-species differences in the structure-activity relationship relating alkyl group length and branching structure to estrogenic activity. This abstract does not necessarily reflect EPA policy.