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INFLUENCE OF DIETARY ARSENIC ON URINARY ARSENIC METABOLITE EXCRETION
Citation:
Carty, C, E. E. Hudgens, R. L. Calderon*, R K. Kwok, AND D J. Thomas. INFLUENCE OF DIETARY ARSENIC ON URINARY ARSENIC METABOLITE EXCRETION. Presented at 5th Intl Conf on Arsenic Exposure and Health Effects, San Diego, CA, July 14-18, 2002.
Description:
Influence of Dietary Arsenic on Urinary Arsenic Metabolite Excretion
Cara L. Carty, M.S., Edward E. Hudgens, B.Sc., Rebecca L. Calderon, Ph.D., M.S.P.H., Richard Kwok, M.S.P.H., Epidemiology and Biomarkers Branch/HSD, NHEERL/US EPA; David J. Thomas, Ph.D., Pharmacokinetics Branch/ETD, NHEERL/US EPA; Roseanne M. Lorenzana, D.V.M, Ph.D, D.A.B.T., Region X, US EPA
In 1997, the US EPA Arsenic Research Plan identified dietary consumption of arsenic as a major confounder in studies of arsenic exposure from drinking water. In support of this plan, we conducted a study to assess the relationship between dietary arsenic and urinary arsenic metabolite excretion in a U.S. Native American population known to have a high fish and shellfish intake. Information regarding daily food and drinking water consumption was obtained from 4-day dietary recall histories and 24-hr. diet diaries. The dietary history focused on foods generally known to have higher levels of arsenic such as fish, shellfish, rice and potatoes. Date of last fish/shellfish meal and approximate portion size were recorded and drinking water and urine samples were collected and analyzed for total inorganic arsenic and methyl and dimethyl arsenic species, respectively.
Of the 100 study participants, more than 70% reported consuming fish or shellfish at least once during the study period. Participants were classified into potential exposure groups based on their self-reported level of seafood consumption during the study period. Individual dietary exposures from food and drinking water were compared with urinary arsenic and arsenic metabolite outputs. The effects of age, sex, and body mass index on these outputs were also examined. These data on the metabolism and elimination of ingested forms of arsenic from foods help to better describe the complex metabolism of arsenic in human populations simultaneously exposed to different forms of arsenic through food and drinking water.
This abstract is of a proposed poster presentation and does not necessarily reflect US EPA policy.
CORRESPONDING AUTHOR: Cara L. Carty, M.S., Epidemiology and Biomarkers Branch, National Health and Environmental Effects Research Laboratory, US EPA, MD 58-C, Research Triangle Park, NC 27711