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ARSENIC SPECIATION IN WATER AND DIETARY SAMPLES BY IC-ICP-MS WITH STRUCTURAL VERIFICATION VIA IC-ESI-MS/MS
Citation:
Creed, J T., P A. Gallagher, B. M. Gamble, A. Heck, AND C A. Schwegel. ARSENIC SPECIATION IN WATER AND DIETARY SAMPLES BY IC-ICP-MS WITH STRUCTURAL VERIFICATION VIA IC-ESI-MS/MS. Presented at Federation of Analytical Chemistry and Spectroscopy Society Meeting, Detroit, MI, October 7-12, 2001.
Impact/Purpose:
The goal is to develop an extraction protocol that mimics the human digestive tract and then to use it to assess the bioavailable fraction of arsenic from complex dietary mixtures such as a daily composite -- to move current methods toward a better human physiologically-based exposure estimate method which approximates the "true" bioavailability of arsenic within an environmental or dietary matrix.
Description:
The two predominate sources of arsenic exposure are water and dietary ingestion. Dietary sources can easily exceed drinking water exposures based on "total" arsenic measurements. This can be deceiving because arsenic's toxicity is strongly dependent on its chemical form and therefore, "total" arsenic measurements do not accurately reflect risk. The limited availability of species specific data in target foods induces a fair amount of uncertainty in the arsenic risk assessment. Thus, species specific data is essential for accurate risk assessment. The ability to quantitatively extract, separate and detect arsenicals from dietary sources has been the subject of numerous publications. Recently, our laboratory has been conducting research in a number of these areas including: 1) utilizing accelerated solvent extraction (ASE) as a potential semi-automated means to extract arsenicals from seafoods; 2) the effect of acidic and basic extraction solvents on the stability of certain arsenicals; 3) the bio-transformatoin of arsenosugars in synthetic stomach type environments; 4) improvement of extraction efficiencies in problrematic seafood matrices; and 5) preservation of AS(III) and number of analytical techniques including IC-ICP-MS and IC-ESI-MS-MS. This presentation will focus on the research highlights and some of the unique capabilities generated in order to better understand species specific stability.