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BRACHIAL EFFLUX OF HYDROPHOBIC ORGANIC COMPOUNDS BY RAINBOW TROUT (ONCORHYNCHUS MYKISS)
Citation:
Fernandez, J D., P N. Fitzsimmons, A D. Hoffman, B C. Butterworth, AND J. W. Nichols. BRACHIAL EFFLUX OF HYDROPHOBIC ORGANIC COMPOUNDS BY RAINBOW TROUT (ONCORHYNCHUS MYKISS). Presented at Sixteenth Annual Sigma Xi Scientific Poster Exhibition, Univ. of Minnesota-Duluth, Duluth, MN, February 21-25, 2000.
Description:
Data on the branchial elimination of hydrophobic compounds has been suggested as key information in the development of PBTK models for fish. The hypothesis is that branchial efflux of high log Kow compounds proceeds to an equilibrium between the afferent blood and expired water. Branchial efflux of high log Kow compounts is difficult to measure because of extremely low chemical concentrations in the expires water. Using transected rainbow trout in respiration-metabolism chambers and adsorption chromatography, chemicals were extracted from large volumes (20 to 100 L) of expired water. Analyses ofthe column extracts were performed by high-resolution GC/MS using isotope dilution.....This data suggests that branchial efflux of high log Kow compounds does proceed to an equilibrium between the afferent blood and expired water.