EPA Science Inventory

MICROWAVE-FACILITATED MULTICOMPONENT REACTIONS UNDER SOLVENT-FREE CONDITIONS

Citation:

Varma*, R S. MICROWAVE-FACILITATED MULTICOMPONENT REACTIONS UNDER SOLVENT-FREE CONDITIONS. Presented at ACS Meeting, Washington, DC, 08/20-25/2000.

Description:

The application of microwave-expedited solvent-free synthetic protocols in multi-component (MCC) reactions will be exemplified by several condensation and cyclization reactions including the rapid one-pot assembly of heterocyclic compounds from in situ generated intermediates. Recent developments in the parallel synthesis of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones employing a solventless Biginelli condensation protocol will be presented; a strategy that is extendible to the rapid and high yield synthesis of DHPM compound libraries using neat mixtures of ketoesters, arylaldehydes, and urea derivatives. The synthesis of imidazo[1,2-a] annulated pyridines, pyrazines and pyrimidines that occurs in the presence of clay will also be described.

Record Details:

Record Type: DOCUMENT (PRESENTATION/ABSTRACT)
Start Date: 08/20/2000
Completion Date: 08/20/2000
Record Last Revised: 06/06/2005
Record Created: 09/26/2003
Record Released: 09/26/2003
Record ID: 60222

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL RISK MANAGEMENT RESEARCH LABORATORY

SUSTAINABLE TECHNOLOGY DIVISION

CLEAN PROCESSES AND PRODUCTS BRANCH