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MICROWAVE-FACILITATED MULTICOMPONENT REACTIONS UNDER SOLVENT-FREE CONDITIONS
Varma*, R S. MICROWAVE-FACILITATED MULTICOMPONENT REACTIONS UNDER SOLVENT-FREE CONDITIONS. Presented at ACS Meeting, Washington, DC, 08/20-25/2000.
The application of microwave-expedited solvent-free synthetic protocols in multi-component (MCC) reactions will be exemplified by several condensation and cyclization reactions including the rapid one-pot assembly of heterocyclic compounds from in situ generated intermediates. Recent developments in the parallel synthesis of 4-aryl-3,4-dihydropyrimidin-2(1H)-ones employing a solventless Biginelli condensation protocol will be presented; a strategy that is extendible to the rapid and high yield synthesis of DHPM compound libraries using neat mixtures of ketoesters, arylaldehydes, and urea derivatives. The synthesis of imidazo[1,2-a] annulated pyridines, pyrazines and pyrimidines that occurs in the presence of clay will also be described.
Record Details:Record Type: DOCUMENT (PRESENTATION/ABSTRACT)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL RISK MANAGEMENT RESEARCH LABORATORY
SUSTAINABLE TECHNOLOGY DIVISION
CLEAN PROCESSES AND PRODUCTS BRANCH