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NONINVASIVE APPROACHES FOR TOXICOLOICAL RESEARCH OF THE LUNG
Citation:
Foster, W. M. AND M. C. Madden. NONINVASIVE APPROACHES FOR TOXICOLOICAL RESEARCH OF THE LUNG. Presented at Society of Toxicology Annual Meeting, San Francisco, CA, March 25-29, 2001.
Description:
Four presentations are planned to overview this topic: 1) a review of gas chromatographic and mass spectrometric methods and sensitivity of these measures of volatile molecules present in exhaled breath. Molecular species present in breath have been predictive markers in a number of research areas, including nutritional status, reperfusion injury during organ transplant, and effect of oxidant stress status on organ viability. 2) The assessment of regional lung retention of inhaled aerosols and particles using laser techniques. Airway measures of regional retention and surface deposition at various depths of the lower respiratory tract have the potential to predict deposited dose and injury sites for respirable hazardous substances. 3) Monitoring the degree of an airway inflammatory state by sputum induction provides materials for specific identification of cellular and biochemical constituents. Analyses based upon induced sputum samples appear to be equal in sensitivity to invasive endoscopic procedures for procuring airway secretions and investigating inflammation in airway disease. 4) Computed tomographic scanning of the cardio-pulmonary system provides quantitative spatial resolution of airway dimensions. Thus functional changes in airway wall geometry can be analyzed to predict sensitivity and injury from various substances, inhaled or delivered vascularly, to the heart and lungs. Each presentation will enumerate current usage of these techniques and provide examples of important new and archived results using these methodologies.