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DETERMINATION OF ROXARSONE, AN ARSENIC ANIMAL-FEED ADDITIVE. AND ITS TRANSFORMATION PRODUCTS IN CHICKEN MANURE BY CE-ICPMS AND UHPLC -ICPMS
Rosal, C G., G M. Momplaisir, AND E M. Heithmar. DETERMINATION OF ROXARSONE, AN ARSENIC ANIMAL-FEED ADDITIVE. AND ITS TRANSFORMATION PRODUCTS IN CHICKEN MANURE BY CE-ICPMS AND UHPLC -ICPMS. Presented at 2002 Winter Conference on Plasma Spectrochemistry, Scottsdale, AZ, January 6-12, 2002.
The overall goals of the task are to apply NERL's core capability in advanced chemical science and technology for maximum benefit in estimating exposures of ecosystems and humans to chemical stressors and to identify emerging pollution concerns, in particular long-range airborne transport of contaminants. This task comprises several subtasks, each with individual objectives:
Subtask 1: screen exposures of National Park PRIMENet ecosystems to chemical stressors, identifying indications of exposure requiring further evaluation, and use these samples evaluate new analytical methods as replacements for standard methods in future assessments of ecosystem contaminant exposures.
Subtask 2: evaluate a new mercury analytical approach with superior performance on complex solid matrices such as biological tissues, and apply the approach to estimating exposure of ecosystems and humans to mercury.
Subtask 3: determine distribution patterns of chemical contaminants in the southern Sierra Nevada Range of California, investigate topographic and weather factors that may influence the distributions, and determine if a correlation exists between contaminant distributions and extirpation patterns of the mountain yellow-legged frog.
Subtask 4: provide analytical methods to measure a number of inorganic and organic arsenic species in a variety of environmental matrices, elucidate the environmental transformations undergone by organoarsenic animal-feed additives, and determine if the potential exists for substantially increased exposure of humans and aquatic organisms to arsenic.
Arsenic animal-feed additives have been extensively used in the United States for their growth- promoting and disease-controlling properties. In particular most broiler chickens are fed roxarsone(3- nitro-4-hydroxyphenylarsonic acid) to control coccidiosis. Disposal of the resulting arsenic-bearing wastes is currently unregulated, and they are frequently used to fertilize crop lands. Because of the high use of roxarsone in certain geographic regions, it is important that the environmental fate of this compound and its transformation products be studied in order to understand their possible impacts on human health and the environment. The U.S. Environmental Protection Agency's Office of Research and Development (ORD) has undertaken such a study in cooperation with the U.S. Geological Survey. Because of the different toxicity levels associated with each arsenic species, it is important to identify and measure the individual species existing in the environment. ORD's National Exposure Research Laboratory in Las Vegas is therefore developing analytical methods to speciate arsenic-containing compounds thought to be relevant to roxarsone transformation and fate. Compounds under investigation include roxarsone (3-NHPAA) and some likely transformation products, specifically arsenite (Aslll), arsenate (AsV), monomethylarsonate (MMA), dimethylarsinate (DMA), 3-amino-4- hydroxyphenylarsonic acid (3-AHPAA), and 4-hydroxyphenylarsonic acid (4-HPAA).