CHRONIC EXPOSURE TO PARTICULATE MATTER AND CARDIOPULMONARY DISEASE
Description:
The objective of this study is to evaluate the association of long term exposure
to air pollution with incident coronary and respiratory disease and with total
mortality. The study population will be the Nurses' Health Study (NHS), an ongoing
prospective cohort study of 121,700 women residing throughout the U.S. We hypothesize
that the incidence of these diseases and total mortality are positively associated
with air pollution and that exposure to air pollution exacerbates existing disease.
We also hypothesize that the association with coronary heart disease will be
greater among diabetics than nondiabetics and that consumption of antioxidants
will modify the association.
Record Details:
Record Type:PROJECT(
ABSTRACT
)
Start Date:01/20/2003
Completion Date:01/19/2006
Record ID:
57883
Keywords:
EPIDEMIOLOGY, HEALTH EFFECTS, AMBIENT AIR, PARTICULATES, SUSCEPTIBILITY, DIET.,
Related Organizations:
Role
:OWNER
Organization Name
:BRIGHAM AND WOMEN'S HOSPITAL, INC.
State
:UT
Project Information:
Approach
:The basic approach is threefold: (1) to use existing data sources to create
a model for exposure to air pollution throughout the U.S.; (2) to link the yearly
average exposure to the residential addresses of the study participants; and
(3) to evaluate the relative risk of the outcomes in the high compared with
the low exposure areas. We will model long-term exposure to air pollution for
the years 1986 through 2000 using data from the EPA's Aerometric Information
Retrieval System (AIRS), the National Emissions Trends database, National Oceanic
and Atmospheric Association, and commercially available traffic count data.
Existing ambient monitoring data from specific sites will be used to supplement
this information. Residential addresses are updated every two years and will
be mapped using geographic information system (GIS) software and linked to the
exposure model. Incident cases of cardiovascular disease and of chronic obstructive
pulmonary disease, asthma, and lung cancer, diagnosed during the study period,
are identified routinely on the NHS biennial self-administered questionnaire.
Cases are confirmed by supplemental questionnaire and review of medical records.
Mortality is reported by next-of-kin and also obtained by regular searches of
the National Death Index. We will estimate the relative risks of these outcomes
associated with air pollution using the proportional hazards model, including
adjustment for smoking, and other confounders. We will also assess interactions
with comorbid diabetes and consumption of antioxidants.
Cost
:$933,602.00
Research Component
:Health Effects
Approach
:
The basic approach is threefold: (1) to use existing data sources to create
a model for exposure to air pollution throughout the U.S.; (2) to link the yearly
average exposure to the residential addresses of the study participants; and
(3) to evaluate the relative risk of the outcomes in the high compared with
the low exposure areas. We will model long-term exposure to air pollution for
the years 1986 through 2000 using data from the EPA's Aerometric Information
Retrieval System (AIRS), the National Emissions Trends database, National Oceanic
and Atmospheric Association, and commercially available traffic count data.
Existing ambient monitoring data from specific sites will be used to supplement
this information. Residential addresses are updated every two years and will
be mapped using geographic information system (GIS) software and linked to the
exposure model. Incident cases of cardiovascular disease and of chronic obstructive
pulmonary disease, asthma, and lung cancer, diagnosed during the study period,
are identified routinely on the NHS biennial self-administered questionnaire.
Cases are confirmed by supplemental questionnaire and review of medical records.
Mortality is reported by next-of-kin and also obtained by regular searches of
the National Death Index. We will estimate the relative risks of these outcomes
associated with air pollution using the proportional hazards model, including
adjustment for smoking, and other confounders. We will also assess interactions
with comorbid diabetes and consumption of antioxidants.
Cost
:$933,602.00
Research Component
:Air Quality and Air Toxics
Approach
:
The basic approach is threefold: (1) to use existing data sources to create
a model for exposure to air pollution throughout the U.S.; (2) to link the yearly
average exposure to the residential addresses of the study participants; and
(3) to evaluate the relative risk of the outcomes in the high compared with
the low exposure areas. We will model long-term exposure to air pollution for
the years 1986 through 2000 using data from the EPA's Aerometric Information
Retrieval System (AIRS), the National Emissions Trends database, National Oceanic
and Atmospheric Association, and commercially available traffic count data.
Existing ambient monitoring data from specific sites will be used to supplement
this information. Residential addresses are updated every two years and will
be mapped using geographic information system (GIS) software and linked to the
exposure model. Incident cases of cardiovascular disease and of chronic obstructive
pulmonary disease, asthma, and lung cancer, diagnosed during the study period,
are identified routinely on the NHS biennial self-administered questionnaire.
Cases are confirmed by supplemental questionnaire and review of medical records.
Mortality is reported by next-of-kin and also obtained by regular searches of
the National Death Index. We will estimate the relative risks of these outcomes
associated with air pollution using the proportional hazards model, including
adjustment for smoking, and other confounders. We will also assess interactions
with comorbid diabetes and consumption of antioxidants.
Cost
:$933,602.00
Research Component
:Particulate Matter
Project IDs:
ID Code
:R830545
Project type
:EPA Grant