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DEVELOPMENT AND APPLICATION OF METHODS TO ASSESS HUMAN EXPOSURE TO PESTICIDES
The goal of this task is to contribute to a better understanding of human exposure to pesticides, especially for small children by developing methods to characterize sources and pathways in and around the residential environment. We will support the science behind FQPA and assist the Office of Pesticide Programs (OPP) in the development of guidelines for the assessment of residential exposure to pesticides. Specific research objectives include: (i) to evaluate and develop methods for measuring pesticides in air using passive/diffusive samplers. Assess and refine devices for the collection of surface transferable pesticide residues and to establish transfer efficiencies; (ii) to develop and apply analytical methods for new and emerging pesticides using both gas and liquid chromatographic methods in support of the National Exposure Research Laboratory's (NERL) Human Exposure Measurement Project; and, (iii) to conduct pilot studies investigating chiral chromatographic methods.
Note: this task is schedule to end September 2003. Two tasks will take its place: method development for emerging pesticides including chiral chemistry applications, and in-house laboratory operations. Field sampling methods are covered under a new task proposed this year.
This research involves the development, validation, and application of methods that can be used for the estimation of human exposure to pesticides, with emphasis on infants and toddlers. Methods that can be used to accurately measure pesticides in environmental media that can be used to estimate respiratory, dermal and nondietary oral exposures, as well as transport mechanisms leading to exposure, are being developed. Methods research under this task includes the measurement of pesticides in air over two-week or longer periods by means of passive/diffusive sampling devices, the measurement of transferable residues using established and novel collection tools to determine transfer efficiencies from common residential surfaces, the development of analytical methodologies for current and new pesticides using gas and liquid chromatographic techniques and finally the evaluation of methods for measuring chiral pesticides in residential exposure media. These measurement methods are needed for a better understanding of children's exposures and to support the requirements of the Food Quality Protection Act (FQPA). In addition, a better understanding is being sought of the transport routes of pesticides within residences and from the outdoors to the indoor environment.