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BIOSENSORS RESEARCH FOR DEVELOPMENT OF INNOVATIVE MONITORING TECHNIQUES THAT SUPPORT EXPOSURE ASSESSMENT RELATED TO THE SUPERFUND PROGRAM
The overall objective of this task is to develop scientifically sound sampling and bioanalytical approaches for screening and monitoring of hazardous wastes. These techniques are expected to provide the Agency with improved screening and field portable methods to characterize, reduce, and control risk to human health and the environment. Specific objectives will include development and characterization of the following concepts:
SPMDs for passive accumulation of TICs
Bioassays for toxic and genotoxic compounds
MIPs for volatile and semivolatile toxic organics
Rapid screening assays using the previously listed components.
One of the approaches for reducing uncertainties in the assessment of human exposure is to better characterize the hazardous wastes that contaminate our environment. A significant limitation to this approach, however, is that sampling and laboratory analysis of contaminated environmental and biological samples, can be slow and expensive; thus, limiting the number of samples that can be analyzed within time and budget constraints. In cases where indicator compounds can be identified, faster, more cost-effective field screening and monitoring methods can increase the amount of information available concerning the location, source and concentration of pollutants which may impact human health and the environment. This task involves the development of scientifically sound analytical methods and approaches to assess and characterize risks to human health posed by chemical pollutants. Research areas include the development and characterization of semipermeable membrane devices (SPMD), molecularly imprinted polymers (MIPs) and toxicity-based bioassays for volatile and semivolatile hazardous wastes and toxic industrial chemicals (TICs).