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NAPHTHALENE TOXICITY IN CD-1 MICE: GENERAL TOXICOLOGY AND IMMUNOTOXICOLOGY
Shopp, G., K. White, M. Holsapple, D. Barnes, AND S. Duke. NAPHTHALENE TOXICITY IN CD-1 MICE: GENERAL TOXICOLOGY AND IMMUNOTOXICOLOGY. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-84/159 (NTIS PB85146397), 1984.
The purpose of this study was to evaluate the acute and subchronic toxicity, and effects on immune function, of naphthalene (NAP) in random-bred CD-1 mice. The acute oral LD50 of this compound was 533 and 710 mg/kg in male and female mice, respectively. Fourteen- and ninety-day daily oral gavage studies were conducted. A dose of 1/2 the LD50 for 14 days resulted in decreased body weight and decreased spleen and thymus weight in females and males, respectively. Doses of up to 1/4 the LD50 for 90 days resulted in no dose related natalities or decreases in body weight. A dose dependent decrease in aryl hydrocarbon hydroxylase was seen. The immunological parameters assessed (i.e. humoral immunity, cell-mediated immunity, lymphocyte responsiveness and bone marrow function) were not affected in these subchronic studies.
Record Details:Record Type: DOCUMENT (REPORT)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT