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USE OF GENOTOXIC ACTIVITY PROFILES IN ASSESSMENT OF CARCINOGENESIS AND TRANSMISSIBLE GENETIC EFFECTS
Citation:
Waters, M., H. Stack, AND A. Brady. USE OF GENOTOXIC ACTIVITY PROFILES IN ASSESSMENT OF CARCINOGENESIS AND TRANSMISSIBLE GENETIC EFFECTS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/D-89/087 (NTIS PB89222830).
Description:
A methodology has been developed to display and evaluate multiple test quantitative information on genetic toxicants for purposes of assessing carcinogenesis and transmissible genetic effects. ose Information is collected from the open literature: either the lowest effective dose (LED) or the highest ineffective dose (HID) tested is recorded for each agent and bioassay system. or each agent in the data base, the quantitative results from genetic and related test systems are represented by computer generated bar graphs "genetic activity profiles". he x-axis unit values correspond to approximately 200 different test systems. ioassay systems are organized according to classes of genetic activity and subdivided by the phylogenetic level of the test organism. The y-axis values are the logarithmically transformed LED or HID values. enetic activity profiles were prepared for use by the International Agency for Research on Cancer (IARC) Working Group for the preparation of IARC Monographs Supplement 6, "Chemicals, Industrial Processes and Industries Associated with Cancer In Humans" (6). hese activity profiles illustrate a quantitative data base on the genetic and related effects of nearly 200 chemicals for which some data are available on carcinogenicity in humans. his information may be used for purposes of comparative chemical hazard assessment. ogether with information derived from animal cancer tests and human epidemiological studies contained in IARC Monographs Supplement 7 (7), assessments may be made regarding potential human health risks associated with exposure to chemical substances.