Science Inventory

PLACENTAL TRANSFER AND FETAL DEPOSITION OF HEXACHLOROBENZENE IN THE HAMSTER AND GUINEA PIG

Citation:

Courtney, K., J. Andrews, AND M. Grady. PLACENTAL TRANSFER AND FETAL DEPOSITION OF HEXACHLOROBENZENE IN THE HAMSTER AND GUINEA PIG. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-85/144 (NTIS PB86101805).

Description:

Hexachlorobenzene (HCB) was administered at dose levels of 0, 1.0, 10.0, or 50.0 mg HCB/kg body wt by gavage to pregnant hamsters and guinea pigs for 6 days up to the time of liver development in the fetus. Samples of maternal fat, thymus, skin, liver, lung, brain, spleen, urinary bladder, muscle, plasma, and blood were analyzed for HCB concentration. Additionally, fetuses, placentas, and yolk sacs were analyzed for HCB content. HCB was found in all tissues assayed. The highest concentrations of HCB were found in the hamster tissues, with the hamster fetuses having a fivefold greater concentration of HCB than the guinea pig fetuses. Comparisons were made of the hamster and guinea pig data with similar data in the mouse and rat.

URLs/Downloads:

PLACENTAL TRANSFER AND FETAL DEPOSITION OF HEXACHLOROBENZENE IN THE HAMSTER AND GUINEA PIG

Record Details:

Record Type: DOCUMENT (REPORT)
Product Published Date: 05/24/2002
Record Last Revised: 04/16/2004
Record ID: 50396

Organization:

U.S. ENVIRONMENTAL PROTECTION AGENCY

OFFICE OF RESEARCH AND DEVELOPMENT

NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY