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COMPARISON OF THE EFFECTS OF ACUTE AND SUBACUTE TREATMENT OF PHENOBARBITAL IN DIFFERENT STRAINS OF MICE
Citation:
Mattox, J., C. Weghorst, B. McFarland, AND M. Pereira. COMPARISON OF THE EFFECTS OF ACUTE AND SUBACUTE TREATMENT OF PHENOBARBITAL IN DIFFERENT STRAINS OF MICE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-89/332 (NTIS PB90199415).
Description:
A strain specificity has been demonstrated for the effect of subsequent administration of phenobarbital. n which diethylnitresamine-initiated hepatocarcinogenesis was presented in C3H mice, inhibited in B6C3F1 (C57BL X C3M) and not affected in C57BL mice. herefore, we examined in these three strains of mice and in C3b6F1 (C3m X C57BL) mice the effect of phenobarbital administered in their drinking water for 4 days or 28 days. he liver weight to body weight ratio was increased by phenobarbital in all types of mice. icrosomal protein concentrations were increased in C57BL mice after 28 days of treatment, in C3M after both 4 days and 28 days and in B6C3F1 after 4 days of treatment. o effect upon microsmal protein was observed in C3b6F1 mice. NA content was increased in C3m mice, both in 4 days and 28 days of treatment groups, while the other strains showed either a decrease or no difference from control. NA synthesis was elevated in all strains of mice after 4 days of treatment with phenobarbital, however, after 28 days of treatment there was either a much reduced increase (C57BL and C3b6f1) or no difference (C3M and B6C3F1) from controls. n all four types of mice after 4 and 28 days of treatment, phenobarbital increased the concentration of cytochrome P-450, the activity of aminopyrine.N. demethylase and 7-ethexyresorufin-A-desthylase and the oxidation of testestorone. he oxidative metabolites of testestorone were similar in the four types of mice.