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STATISTICAL APPROACH TO PREDICTING CHRONIC TOXICITY OF CHEMICALS TO FISHES FROM ACUTE TOXICITY TEST DATA
Citation:
Mayers, F., G. Krause, M. Ellersieck, AND G. Lee. STATISTICAL APPROACH TO PREDICTING CHRONIC TOXICITY OF CHEMICALS TO FISHES FROM ACUTE TOXICITY TEST DATA. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/R-92/091 (NTIS PB92169655), 1992.
Description:
A comprehensive approach to predicting chronic toxicity from cute toxicity data was developed in which simultaneous onsideration is given to concentration, degree of response, and ime course of effect. onsistent endpoint (lethality) and degree of response (0 percent) were used to compare acute and chronic ests. redicted no-effect concentrations were highly accurate 92 percent of the time (within a factor of 2.0 of the limits of the maximum cceptable toxicant concentrations for lethality) and did not vary y more than a factor of 4.8 when the technique was applied to a ata base of 18 chemicals and 7 fish species. rowth effects can e predicted from chronic lethality, but reproductive effects hould not be.
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STATISTICAL APPROACH TO PREDICTING CHRONIC TOXICITY OF CHEMICALS TO FISHES FROM ACUTE TOXICITY TEST DATA