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EFFECTS OF PCB (AROCLORR 1254) ON NON-SPECIFIC IMMUNE PARAMETERS IN RHESUS (MACACA MULATA) MONKEYS.
Citation:
Tryphonas, H., M. Luster, K. White, Jr., P. Naylor, M. Erdos, G. Burleson, D. Germolec, M. Hodgen, S. Hayward, AND D. Arnold. EFFECTS OF PCB (AROCLORR 1254) ON NON-SPECIFIC IMMUNE PARAMETERS IN RHESUS (MACACA MULATA) MONKEYS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-92/324 (NTIS PB92232867), 1991.
Description:
The effects of low level chronic polychlorinated biphenyl - Aroclor 1254 - (PCB) exposure were investigated on nonspecific immune parameters in female rhesus (Macaca mulatta) monkeys. Five groups of monkeys were orally administered PCB at concentrations of 0, 5, 20, 40, or 80 ug/kg body weight/day. Immunotoxicity testing was initiated after 55 months of exposure. he serum hemolytic complement activity in all PCB treated groups was significantly higher than controls. A statistically significant dose-related increase in natural killer cell activity was observed. Similarly, a statistically significant dose-related increase was observed for hymosin alpha-4 levels. tatistically significant increases were observed for interferon production while the production of tumor necrosis factor by monocytes in the PCB treated group was not different from controls. The results indicated that long term exposure to PCB modulate several nonspecific immune parameters.