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LOCALIZATION OF THE MOUSE THYMIDINE KINASE GENE TO THE DISTAL PORTION OF CHROMOSOME 11
Hozier, J., J. Sawyer, N. DeVassal, M. Applegate, D. Clive, AND M. Moore. LOCALIZATION OF THE MOUSE THYMIDINE KINASE GENE TO THE DISTAL PORTION OF CHROMOSOME 11. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-91/177 (NTIS PB91233395), 1991.
We report the regional mapping of the thymidine kinase (tk-1) gene in the mouse using two complementary analyses: 1) investigation of chromosome aberrations associated with tx-1 gene inactivation in the L5178Y TX+/-3.7.2c cell line and (2) in situ molecular hybridization of a cloned tk-1 cDNA probe to mitotic chromosomes of this cell line. he consensus location for both analyses is 11B2-C1. omparison of the mouse tk-1 gene localization with evidence that the homologous TX-I gene is located distally on the large arm of chromosome 17 appears to extend the region of homology between MMU11 and HSA17 to include the distal segments of both.
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Record Details:Record Type: DOCUMENT (REPORT)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT