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1-CHLOROMETHYLPYRENE; A SKIN SENSITIZER AND GENOTOXIN
Citation:
Ashby, J., J. Gallagher, M. Kohan, H. Tinwell, I. Kimber, D. Paton, R. Callander, AND I. Chouroulinkov. 1-CHLOROMETHYLPYRENE; A SKIN SENSITIZER AND GENOTOXIN. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-90/174 (NTIS PB91115782), 1990.
Description:
1-Chloromethylpyrene has been evaluated as a model mutagen and toxin related to the ultimate electrophiles derived from BaP and 1-Nitropyren. t was mutagenic to salmonella 6100 picograms/plate) and exceptionally reactive to DNA when assessed by the postlabeling assay. MP was inactive in a mouse bone marrow micronucleus assay when administered by gavage probably due to hydroylis whose kinetics have been studied (half time 23 min at 37 C). owever as expected it was a potent skin toxin as determined by its activity as a mitogen to mouse skin and its contact allergenicity, as determined using the local lymph node proliferative assay. T is concluded that 1-CMP will probably be a potent human skin carcinogen and contact allergen.