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EFFECTS OF LINDANE AND LINURON ON CALCIUM METABOLISM, MORPHOMETRY, AND THE KIDNEY
Andrews, J. AND L. Gray. EFFECTS OF LINDANE AND LINURON ON CALCIUM METABOLISM, MORPHOMETRY, AND THE KIDNEY. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-90/047 (NTIS PB90217840), 1990.
The effects of lindane and linuron on calcium metabolism, bone morphometry and the kidney. xperiments were performed to investigate the effects of lindane and linuron on calcium metabolism, femur morphometry and nephrotoxicity. ong-Evans hooded rats were dosed daily for 10 weeks with 0, 10 or 20 mg lindane or 10, 20 or 40 mg linuron/kg body weight beginning at leaning. indane significantly decreased urinary calcium concentration, serum alkaline phosphatase concentration and the cross-sectional medullary area of the bone. indane was nephrotoxic at both dose levels as demonstrated by elevated kidney weights, kidney-to-body-weight ratios, enzymuria, tubule regeneration and hyaline droplet degeneration. inuron significantly reduced medullary crossectional area at the two higher dose levels and decreased the total femur crossectional area at the highest dose level in the absence of effects on calcium excretion. emur density and strength were also significantly reduced at the highest dose level of linuron. either compound affected the serum concentrations f parathyroid hormone or 1,25-dihydroxy Vitamin D3. oth linuron and lirdane exposure significantly increased serum cholesterol concentrations and reduced serum triglyceride concentrations. oth compounds affected calcium metabolism and/or one morphometry but possibly by different mechanisms since the effects were not the same.
Record Details:Record Type: DOCUMENT (REPORT)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY