You are here:
THE TIME-COURSE AND SENSITIVITY OF MUCONIC ACID AS A BIOMARKER FOR HUMAN ENVIRONMENTAL EXPOSURE TO BENZENE
Citation:
Buckley, T., A.B. Lindstrom, V. Highsmith, W. Bechtold, AND L. Sheldon. THE TIME-COURSE AND SENSITIVITY OF MUCONIC ACID AS A BIOMARKER FOR HUMAN ENVIRONMENTAL EXPOSURE TO BENZENE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/A-92/248 (NTIS PB93121044).
Description:
Preliminary results are presented that show the effect of an increased benzene exposure on the urinary elimination of trans,trans-muconic acid (MA) for an adult male. These results were generated from a controlled exposure experiment where by an individual was exposed to benzene during a shower with gasoline-contaminated ground water. Based on measured air and water concentrations, it is estimated that the 25 minute shower and drying-off exposure period resulted in an inhalation and dermal absorbed dose of 122 ug and 19 ug, respectively, yielding an average dose rate of 334 ug/h during the shower period. The measured background dose rate of 1.2 ug/h was exceeded by a factor of 278 during the shower exposure. The average urinary MA elimination rate increased from 3.7 ug/h during the 30 h period before the exposure to 17.9 ug/h during the 22 h period after the exposure. The post-exposure profile of muconic acid elimination (ug/h) was characterized by two minor peaks (47 and 35 ug/h) occurring within 3 h and a major peak (61 ug/h) at approximately 11 h.
URLs/Downloads:
THE TIME-COURSE AND SENSITIVITY OF MUCONIC ACID AS A BIOMARKER FOR HUMAN ENVIRONMENTAL EXPOSURE TO BENZENE