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CARDIOPATHIC EFFECT OF 1,2,3-TRICHLOROPROPANE AFTER SUBACUTE AND SUBCHRONIC EXPOSURE IN RATS
Citation:
Merrick, B., M. Robinson, AND L. Condie. CARDIOPATHIC EFFECT OF 1,2,3-TRICHLOROPROPANE AFTER SUBACUTE AND SUBCHRONIC EXPOSURE IN RATS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-91/131 (NTIS PB91213629), 1991.
Description:
1,2,3-Trichloropropane (1,2,3-TCP) is an industrial water contaminant with potential for human exposure by the oral route. The systemic toxicology of 1,2,3-TCP was evaluated after subacute or subchronic exposure in male and female Sprague Dawley rate. Animals were treated with 0.01, 0.05, 0.20, and 0.80 mmole/kg/day for 10 days and 0.01, 0.05, 0.10 and 0.40 mmole/kg/day for 80 days. hemical exposure was by oral gavage in corn oil. ethality did not occur in either study. oxicity was observed primarily in the high dose group of subacute and subchronically treated rats of both sexes. eight gain suppression occurred at 0.8 mmole/kg (118 mg/kg) after 10 days. fter 90 days exposure to 0.40 mmole/kg, growth was 37% and 25% of control values for males and females, respectively. hen major organs weights were normalized by weight, liver end kidney values were generally increased relative to control in the two highest dose groups after 10 and 90 day chemical exposure. erum chemistries and histopathology indicated a mild hepatotoxic response to 1,2,3-TCP in the high dose group of each study but did not support any renal toxicity. hymic weight reduction due to atrophy occurred at 10 days exposure in high dose groups hut was normal in all groups after 90 day treatment. The primary histologic finding in this study was an inflammation-associated cardiopathy produced by 1,2,3-TCP. yocardial necrosis end degeneration occurred in a diffuse pattern with marked eosinophilia of effected cells. ale and female animals showed a cardiopathic response only et 0.8 mmole/kg of 1,2,3-TCP after 10 day exposure. n the subchronic study, the incidence of cardiopathy was more prevalent in males than females. n addition to cardiac effects, 90 day chemical exposure produced bile duct hyperplasia in 40% and 80% of males and females, respectively. his observation may be significant since five other neoplastic and proliferative lesions were observed in rats receiving 1,2,3-TCP subchronically. hus, this study demonstrates heart and liver were target organs for 1,2,3-TCP toxicity, and suggests 1,2,3-TCP exposure may be involved in carcinogenesis.