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BILIARY EXCRETION AND TISSUE DISTRIBUTION OF CADMIUM-109 ADMINISTERED TO RATS
Citation:
Mullen, A. AND R. Mosley. BILIARY EXCRETION AND TISSUE DISTRIBUTION OF CADMIUM-109 ADMINISTERED TO RATS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/3-80/085 (NTIS PB80217995), 1980.
Description:
The difference in the excretion of cadmium in urine and feces was measured in rats with either ligated or intact bile ducts. Three days following a single oral-administration of cadmium-109 plus stabe cadmium chloride, 0.004 percent of the dose was excreted in the urine of rats with intact bile ducts, while 0.05 percent was excreted in urine of rats with ligated bile ducts. While 82 percent of the dose was excreted via the feces of intact rats, 71 percent was recovered in feces from rats with ligated bile ducts. The amount of the dose recovered in tissue was 13 percent for intact rats and 30 percent for ligated rats. Following intravenous administration of cadmium, rats with intact bile ducts excreted about 0.5 percent of the dose in urine versus 2 percent for rats with ligated bile ducts. About 8 percent of the dose was excreted via the feces of rats with intact bile ducts compared to only about 0.6 percent by ligated rats. The amount of the dose recovered in the tissues was 91 and 96 percent respectively for intact and ligated rats. The liver appeared to be the primary organ of concern during the course of this study, although cadmium was also retained in the kidneys and bone.