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MUTAGENIC AND CARCINOGENIC POTENCY OF EXTRACTS OF DIESEL AND RELATED ENVIRONMENTAL EMISSIONS: SUMMARY AND DISCUSSION OF THE RESULTS
Citation:
Nesnow, S. AND J. Lewtas. MUTAGENIC AND CARCINOGENIC POTENCY OF EXTRACTS OF DIESEL AND RELATED ENVIRONMENTAL EMISSIONS: SUMMARY AND DISCUSSION OF THE RESULTS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-81/605 (NTIS PB83149328), 1981.
Description:
The proposed conversion from gasoline powered automobiles to diesel powered vehicles has prompted the Environmental Protection Agency to evaluate the potential health effects associated with exposure to diesel emissions. At present, there is no direct epidemiological link between this exposure and human health. Therefore, a research program was constructed to compare the health effects associated with diesel emissions with those from other emission sources for which epidemiological information was available. The emission sources chosen were cigarette smoke, roofing tar, and coke oven. An additional comparitive emission source which was evaluated was a gasoline catalyst engine. Respirable particles from a variety of combustion sources have the potential of being carcinogenic and mutagenic. The objective of these studies was to determine the relative biological activity of the organic material adsorbed on these particles in both In Vitro mutagenesis and In Vitro and In Vivo carcinogenesis bioassays.