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HIGH DOSES OF ASPARTAME HAVE NO EFFECTS ON SENSORIMOTOR FUNCTION OR LEARNING AND MEMORY IN RATS
Tilson, H., J. Hong, AND T. Sobokta. HIGH DOSES OF ASPARTAME HAVE NO EFFECTS ON SENSORIMOTOR FUNCTION OR LEARNING AND MEMORY IN RATS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-91/008 (NTIS PB91177360), 1991.
Acute or repeated (14 days) intragastric administration of L-d-aspartyl-L-phenylalanine methyl ester suspended in saline and Tween-80 in doses of up to 1,000 mg/kg had no significant effect in male Fischer-344 rats on routine measures of sensorimotor function, including spontaneous motor activity, acoustic startle reflex and prepulse inhibition. ther experiments found that aspartame (500 or l,000mg/kg) had no significant effect on acquisition of passive or active avoidance or a spatial, reference memory task in the Morris water maze. eries of separate studies found that aspartame had no effects in rats fasted 24 hours prior to testing, or if it were suspended in carboxymethylcellulose or administered by the intraperitoneal route. nder the conditions of these experiments, large doses of aspartame have no significant neurobiological effects in adult rats as measured by procedures known to be sensitive to the neurobiological effects of neurotoxicants, including convulsants, organochlorine insecticides and heavy metals.
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Record Details:Record Type: DOCUMENT (REPORT)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY