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ESTIMATION OF ACUTE TOXICITY BY FITTING A DOSE-TIME RESPONSE SURFACE
Citation:
Sun, K., G. Krause, F. Mayer, M. Ellersieck, AND A. Basu. ESTIMATION OF ACUTE TOXICITY BY FITTING A DOSE-TIME RESPONSE SURFACE. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-95/374.
Description:
In acute toxicity testing, organisms are continuously exposed to progressively increasing concentrations of a chemical and deaths of test organisms are recorded at several selected times. he results of the test are traditionally summarized by a dose-response curve, and the time course of effect is usually ignored for lack of a suitable model. odel which integrates the combined effects of dose and exposure duration on response is derived from the biological mechanisms of aquatic toxicity, and a statistically efficient approach for estimating acute toxicity by fitting the proposed model is developed in this paper. he proposed procedure has been computerized as software and a typical data set is used to illustrate the theory and procedure. he new statistical technique is also tested by a data base of a variety of chemical and fish species.