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MICROINJECTION OF DYNORPHIN INTO THE HIPPOCAMPUS IMPAIRS SPATIAL LEARNING IN RATS
Citation:
McDaniel, K., W. Mundy, AND H. Tilson. MICROINJECTION OF DYNORPHIN INTO THE HIPPOCAMPUS IMPAIRS SPATIAL LEARNING IN RATS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-90/234 (NTIS PB91117044).
Description:
The effect of hippocampal dynorphin administration on learning and memory was examined in spatial and nonspatial tasks. ilateral infusion of dynorphin A(1-8)(DYN; 10 or 20 ug in one ul) into the dorsal hippocampus resulted in dose-related impairment of spatial working memory in a radial maze win-stay task. ubsequent experiments found that acquisition of a reference memory task in the water maze was impaired by DYN injections (20 ug/ul) in the dorsal hippocampus, but not in the ventral hippocampus and that this impairment could be blocked by naloxone. n a nonspatial task straining DYN injections in the dorsal hippocampus had no effect on retention of step-through passive avoidance. hese results suggest that dynorphin specifically interferes with spatial learning and memory, and that this effect is mediated by aapt receptors in the dorsal hippocampus.
