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DOSE-DEPENDENCY OF 2-ACETYLAMINOFLUORENE BINDING TO LIVER DNA AND HEMOGLOBIN IN MICE AND RATS
Citation:
Pereira, M., L. Lin, AND L. Chang. DOSE-DEPENDENCY OF 2-ACETYLAMINOFLUORENE BINDING TO LIVER DNA AND HEMOGLOBIN IN MICE AND RATS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-81/141 (NTIS PB82247503).
Description:
The carcinogenic activity of 2-acetylaminofluorene (2-AAF) in mice and rats has been accurately described so that it is a suitable archetypical chemical for investigations of parameters of cross-species variation. The results of the study supported a pharmacokinetic model that related the metabolism of 2-AAF to reactive metabolites to the binding of the metabolite to DNA and hemoglobin. The results do not support a relationship of macromolecular binding to carcinogenic potency.
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DOSE-DEPENDENCY OF 2-ACETYLAMINOFLUORENE BINDING TO LIVER DNA AND HEMOGLOBIN IN MICE AND RATSRecord Details:
Record Type:DOCUMENT( REPORT )
Product Published Date:05/24/2002
Record Last Revised:04/16/2004
Record ID:
40081