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CYTOGENETIC EFFECTS OF PHOSPHINE INHALATION BY RODENTS
Kligerman, A., M. Bryant, C. Doerr, G. Erexson, P. Kwanyuen, AND J. McGee. CYTOGENETIC EFFECTS OF PHOSPHINE INHALATION BY RODENTS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-95/046.
Phosphine (PH3) is a highly toxic grain fumigant that can be produced from the reaction of metal phosphides with water. o determine the in vivo cytogenetic effects of inhalation of PH3, male CD-1 mice were exposed to either 0, 5, 10, or 15 ppm target concentrations of PH3 for 6 h. Twenty h after the termination of exposure, the spleens of the mice were removed, macerated, and the splenocytes cultured for analyses of sister chromatid exchanges, chromosome aberrations, and micronuclei in cytochalasin B-induced binucleated cells. n addition, bone marrow smears were made for the analysis of micronuclei in polychromatic erythrocytes. oincrease in any of the cytogenetic endpoints was found at any f the concentrations examined. he only statistically significant response was a concentration-related slowing of the cell cycle in the splenocytes.
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Record Details:Record Type: DOCUMENT (REPORT)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT
NATIONAL HEALTH AND ENVIRONMENTAL EFFECTS RESEARCH LABORATORY