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SULFAMETHOXAZOLE-TRIMETHOPRIM TREATMENT OF GUINEA PIGS INFECTED WITH 'LEGIONELLA PNEUMPOPHILA'
Plouffe, J., M. Para, AND G. Bollin. SULFAMETHOXAZOLE-TRIMETHOPRIM TREATMENT OF GUINEA PIGS INFECTED WITH 'LEGIONELLA PNEUMPOPHILA'. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-84/393.
Legionnaires' disease is a bacterial pneumonia caused by Legionella pneumophila. Many antibiotics inhibit the growth of L. pneumophila in vitro, but only erythromycin and rifampin have been clinically effective. Parallel results have been observed in guinea pigs infected ip with L. pneumophila. Antibiotics that were ineffective in this model include penicillin, tetracycline, chloramphenicol, gentamicin, and many cephalosporins. Using the guinea pig model, the authors studied the in vivo efficacy of sulfamethoxazole-trimethoprim. (Copyright (c) 1984 by the University of Chicago.)
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Record Details:Record Type: DOCUMENT (REPORT)
Organization:U.S. ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF RESEARCH AND DEVELOPMENT