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A GENOTOXIC ASSESSMENT OF ENVIRONMENTAL TOBACCO SMOKE USING BACTERIAL BIOASSAYS
Citation:
Claxton, L., R. Morin, T. Hughes, AND J. Lewtas. A GENOTOXIC ASSESSMENT OF ENVIRONMENTAL TOBACCO SMOKE USING BACTERIAL BIOASSAYS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-89/014 (NTIS PB89236327).
Description:
Recently, the National Research Council in the U.S.A. stated that labOratory studies of environmental tobacco smoke (ETS) should be important in identifying ETS carcinogens and their concentrations in typical daily environments, and in understanding horn these compounds contribute to ETS dose-response relationships. his paper demonstrates that integrated chemical and bacterial mutagenicity information can be used to identify ETS genotoxicants, monitor human exposure, and make comparative assessments. pproximately 1/3 of the ETS constituents for which there is quantitative analytical chemistry information also have associated genotoxicity information. or example, 11 of the quantitated compounds are animal carcinogens. Work presented in this paper demonstrates that both the nonparticle-bound semi-volatile and the particulate-bound organic material contain bacterial mutagens. These ETS organics give an equivalent of 86,000 revertants per cigarette. n addition, this article summarizes efforts to estimate ETS bacterial mutagenicity, to use bacterial tests for the monitoring of ETS-impacted indoor environments, and to use bacterial assays for the direct monitoring of human exposure.