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EFFECTS OF HYPERTHERMIA AND HYPERTHERMIA PLUS MICROWAVES ON RAT BRAIN ENERGY METABOLISM
Citation:
Sanders, A. AND W. Joines. EFFECTS OF HYPERTHERMIA AND HYPERTHERMIA PLUS MICROWAVES ON RAT BRAIN ENERGY METABOLISM. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-84/024 (NTIS PB84204098).
Description:
The effects of hyperthermia, alone and in conjunction with microwave exposure, on brain energetics were studied in anesthetized male Sprague-Dawley rats. The effects of temperature on adenosine triphosphate concentration (ATP) and creatine phosphate concentration (CP) was determined in the brains of rats that were maintained at 35.6, 37.0, 39.0, and 41.0C brain (ATP) and (CP) were down 6.0, 10.8, and 29.2%, and 19.6, 28.7, and 44%, respectively, from the 35.6C control concentrations. Exposure of the brain to 591-MHz radiation at 13.8 mW/cm sq for 0.5, 1.0, 3.0, and 5.0 min caused further decreases (below those observed for 30C hyperthermia only) of 16.0, 29.8, 22.5, and 12.3% in brain (ATP), and of 15.6, 25.1, 21.4, and 25.9% in brain (CP) after 0.5, 1.0, 3.0, and 5.0 min, respectively. Recording of brain reduced nicotinamide adenine dinucleotide (NADH) fluorescence before, during, and after microwave exposure showed an increase in NADH fluorescence during microwave exposure that returned to preexposure levels within 1 min postexposure.