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RISK ASSESSMENT OF OXIDANT GASES AND PARTICULATE AIR POLLUTANTS: UNCERTAINTIES AND RESEARCH NEEDS
Citation:
Samet, J., W. Pepelko, B. Sonawane, G. Hatch, K. Driscoll, AND G. Oberdorster. RISK ASSESSMENT OF OXIDANT GASES AND PARTICULATE AIR POLLUTANTS: UNCERTAINTIES AND RESEARCH NEEDS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-95/339.
Description:
The assessment of risks to human health associated with exposure to oxidant air pollutants has not received adequate attention despite the recognized public health threat posed by the ubiquitous presence of these compounds in the environment. n this article, research needs and uncertainties at each of the steps in the risk assessment of oxidant air pollutants, Hazard Identification, Dose-Response Assessment, Exposure Assessment and Risk Characterization, are identified. any of these limitations and uncertainties arise at the interface between the laboratory and the regulatory arenas. herefore, as a case study, relevant methodological problems associated with the application of experimental findings to the risk assessment of respirable dusts are also discussed. hese issues include the extrapolation of animal data to the human case and extrapolation from high-dose to environmentally relevant, low-level exposures.