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ACUTE EXPOSURE TO TRIS (2-CHLOROETHYL) PHOSPHATE HIPPOCAMPAL NEURONAL LOSS AND IMPAIRS LEARNING IN RATS
Citation:
Tilson, H., B. Veronesi, R. McLamb, AND H. Matthews. ACUTE EXPOSURE TO TRIS (2-CHLOROETHYL) PHOSPHATE HIPPOCAMPAL NEURONAL LOSS AND IMPAIRS LEARNING IN RATS. U.S. Environmental Protection Agency, Washington, D.C., EPA/600/J-90/417 (NTIS PB91171728).
Description:
Adult female, Fischer 344 rats were exposed to 275 mg/kg of tris(2- chloroethyl)phosphate (TRCP) by gavage. RCP produced consistent signs of convulsive activity within 60-90 minutes after dosing and extensive loss of CA1 hippocampal pyramidal cells when examined 7 days after dosing. t the light microscopic level, toxic effects of TRCP on pyramidal cells in the CA3, and CA4 and granule cells in the dentate gyrus were less severe than on the CA1 cells. he seizure-related and neurohistological effects of TRCP were significantly attenuated by pretreatment with atropine or chlordiazepoxide, suggesting that the hippocampal damage was related to the seizures produced by TRCP. n a second experiment designed to assess the potential health risk associated with TRCP, exposed rats were mildly impaired in the acquisition of a reference memory task in a water maze. owever, TRCP-exposed rats were consistently impaired in performing a repeated acquisition task in the water maze. hese data underscore the potential health risk associated with exposure to TRCP and support the conclusion that the hippocampus is ultimately involved in spatial memory in rats.