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Benchmark Dose (BMD) Modeling in Practice – A Practical Guide to BMD in the Context of Regulatory Risk Assessment
Citation:
Davis, Allen, M. Wheeler, AND S. White. Benchmark Dose (BMD) Modeling in Practice – A Practical Guide to BMD in the Context of Regulatory Risk Assessment. Toxicology and Risk Assessment Conference, Dayton, OH, April 24 - 27, 2023.
Impact/Purpose:
Benchmark dose modeling workshop for risk assessment conference
Description:
This workshop will cover applied benchmark dose-response (BMD) modeling and analysis with a special emphasis on practical issues in the context of risk assessment. Participants will learn basics for BMD modeling of dichotomous and continuous response data and be given the tools to understand the importance of the BMD analytical pipeline, with a particular focus on setting the benchmark response (BMR) for particular endpoints and conversion to human equivalent doses (HEDs). Following this introduction, participants will be exposed to BMD modeling topics/situations that have been encountered in practice and incorporated in published reports but may be only briefly covered in current guidance documents. This will cover topics such as when/if it is appropriate to drop high-dose groups prior to modeling, the visual inspection of modeling results, and current efforts to incorporate BMD estimates from different models using model averaging. Participants will be given the opportunity to participate in a real-time, hands-on learning environment using the current online version of BMDS and will also learn about multiple BMD software products can be used in a complementary fashion to achieve confidence in results and guide decision making. Disclaimer: The views expressed in the abstract are those of the authors and do not necessarily reflect the views or policies of the U.S. Environmental Protection Agency or the National Institute of Environmental Health Sciences.