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Towards Precision Ecotoxicology: Leveraging Evolutionary Conservation of Pharmaceutical and Personal Care Product Targets to Understand Adverse Outcomes Across Species and Life Stages
Citation:
Brooks, B., S. van den Berg, D. Dreier, C. LaLone, S. Owen, S. Raimondo, AND X. Zhang. Towards Precision Ecotoxicology: Leveraging Evolutionary Conservation of Pharmaceutical and Personal Care Product Targets to Understand Adverse Outcomes Across Species and Life Stages. ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY. Society of Environmental Toxicology and Chemistry, Pensacola, FL, 43(3):526-536, (2024). https://doi.org/10.1002/etc.5754
Impact/Purpose:
This manuscript is an invited contribution in a Special Issue for Environmental Toxicology and Chemistry on the challenges around pharmaceuticals and personal care products (PPCPs) in the environment. Approximately 20 papers will contribute to this Special Issue, covering diverse research topics to provide readers with an authoritative and up-to-date understanding of the subject.
Description:
Translation of environmental science to the practice aims to protect biodiversity and ecosystem services, and our future ability to do so relies on the development of a precision ecotoxicology approach wherein we leverage the genetics and informatics of species to better understand and manage the risks of global pollution. A little over a decade ago, a workshop focusing on the risks of pharmaceuticals and personal care products (PPCPs) in the environment identified a priority research question, “What can be learned about the evolutionary conservation of PPCP targets across species and life stages in the context of potential adverse outcomes and effects?” We review the activities in this area over the past decade, consider prospects of more recent developments, and identify future research needs to develop next-generation approaches for PPCPs and other global chemicals and waste challenges.
URLs/Downloads:
DOI: Towards Precision Ecotoxicology: Leveraging Evolutionary Conservation of Pharmaceutical and Personal Care Product Targets to Understand Adverse Outcomes Across Species and Life Stages