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Advancing the Science of PFAS Mixtures Assessment: Draft Framework for Estimating Noncancer Health Risks Associated with Mixtures of Per- and Polyfluoroalkyl Substances (PFAS)
Citation:
Lambert, J. Advancing the Science of PFAS Mixtures Assessment: Draft Framework for Estimating Noncancer Health Risks Associated with Mixtures of Per- and Polyfluoroalkyl Substances (PFAS). Society of Toxicology Webinar, Cincinnati, OH, January 10, 2024. https://doi.org/10.23645/epacomptox.24977913
Impact/Purpose:
Presentation to the Society of Toxicology webinar given January 2024
Description:
Several related research efforts are in-progress in the US EPA to inform a large(r) hazard and dose-response landscape for per- and polyfluoroalkyl substances (PFAS); such data may be critical to informing data-poor mixture PFAS. The expressed objective is to identify dose-response metrics that could be used in one or more of the component-based mixture assessment approaches: 1) Molecular/cellular points-of-departure POD(s) (e.g., transcriptomic pathway-based; in vitro cell bioactivity). 2) Read-across/surrogate chemical POD(s). Considering data-poorness of the PFAS universe, integration of new approach methods (NAMs) could be critical.
URLs/Downloads:
DOI: Advancing the Science of PFAS Mixtures Assessment: Draft Framework for Estimating Noncancer Health Risks Associated with Mixtures of Per- and Polyfluoroalkyl Substances (PFAS)
LAMBERT_OVERVIEW PFAS MIXTURES FRAMEWORK FOR SOT_V4.PDF (PDF, NA pp, 876.094 KB, about PDF)